Webinar • Members
Join Webinar #9 in Genoskin's Scientific Series!
This session will feature an in-depth presentation by Dr. Etienne Meunier, a leading expert in inflammasome biology and innate immunity.
Discover the NLRP1 Inflammasome’s Role in Epithelial Immunity
Join Genoskin to explore how the NLRP1 inflammasome acts as a critical immune sensor in epithelial tissues, safeguarding the body against environmental and infectious threats. Dr. Etienne Meunier will present his team’s latest findings on the ribotoxic stress response and its role in activating the NLRP1 inflammasome. His cutting-edge research uncovers the molecular mechanisms that protect epithelial barriers, shedding light on human-specific immune defense systems.
This webinar offers valuable insights into the intricate pathways that regulate innate immunity, providing a foundation for advancements in therapeutic strategies for immune-related diseases and conditions. Don’t miss this opportunity to learn from a leading expert in the field!
When: February 26, 2025
🕔 Time: 8:00 AM PT / 11:00 AM ET / 5:00 PM CET
Register now to gain valuable insights into human immune defense mechanisms:
Discover the cutting-edge research on the NLRP1 inflammasome in this engaging webinar featuring Dr. Etienne Meunier.
Inflammasomes are critical intracellular protein complexes that play a pivotal role in immunity against pathogens. They regulate pyroptosis—a form of programmed cell death—and release key inflammatory cytokines such as IL-1β and IL-18, essential for controlling microbial infections. While much of our understanding of inflammasomes stems from rodent models or immune cell studies, these do not fully capture the unique characteristics of human inflammasomes.
This webinar will explore the novel immune functions of the human NLRP1 inflammasome, predominantly expressed in epithelial tissues like skin and airways, in response to environmental and infectious threats. Join us as we delve into the ribotoxic stress response pathway and its implications for understanding immune defense in human biology.
Resources related to Dr. Meunier’s inflammasome research
● Planès R, Pinilla M, Santoni K, et al. Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells. Mol Cell. 2022;82(13):2385-2400.e9.
● Pinilla M, Mazars R, Vergé R, et al. EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption. J Exp Med.
● Rozario P, Pinilla M, Gorse L, et al. Mechanistic basis for potassium efflux-driven activation of the human NLRP1 inflammasome. Proc Natl Acad Sci U S A. 2024;121(2):e2309579121.
About Dr. Etienne Meunier
Dr. Etienne Meunier brings a wealth of expertise in innate immunity and inflammasome biology. With a PhD from Toulouse, France, and a postdoctoral tenure in Basel, Switzerland, he has made groundbreaking discoveries on host cytosolic anti-bacterial immunity and inflammasome activation mechanisms. Now leading his own laboratory at the IPBS institute, Dr. Meunier’s work focuses on understanding human-specific regulators of immune responses.
Recognized with prestigious awards such as the CNRS Bronze Medal, Dr. Meunier is at the forefront of exploring how human epithelial inflammasomes contribute to health and disease.
Additional resources on Dr. Meunier’s previous work
● Lefèvre L, Lugo-Villarino G, Meunier E, et al. The C-type lectin receptors dectin-1, MR, and SIGNR3 contribute both positively and negatively to the macrophage response to Leishmania infantum. Immunity. 2013;38(5):1038-1049.
● Meunier E, Dick MS, Dreier RF, et al. Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases. Nature. 2014;509(7500):366-370.
● Meunier E, Wallet P, Dreier RF, et al. Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida. Nat Immunol. 2015.
